Best Nattokinase Supplement

Best Nattokinase supplement (capsule) is a dietary supplement mainly composed of nattokinase. The nattokinase component contained has the functions of dissolving blood clots, reducing blood viscosity, improving blood circulation, softening blood vessels, and increasing vascular elasticity. Used worldwide as a thrombolytic agent for cerebral infarction, myocardial infarction, and other conditions.

Nattokinase (NK), also known as subtilisin NAT, is a serine protease produced by Bacillus subtilisl natto during the fermentation process of natto. Due to its ability to dilute blood (inhibit platelet aggregation), dissolve blood clots (promote fibrinolysis), and regulate blood lipids (assist in lowering blood lipids), it is known as the "vascular scavenger".

In 1980, it was discovered in Natto that it consists of 275 amino acids arranged in a fixed manner, with a molecular weight of 27724. It has a unique function of decomposing blood clots, and its active effect is represented by the intrinsic unit FU.

There is a dynamic balance system in the human blood that revolves around the fibrinolytic state, including two opposing parts: the coagulation system and the anticoagulant system. This dynamic balance system ensures both the potential coagulability of the blood and the fluid state of the blood at all times. As people age, the function of this system gradually decreases, and imbalance can lead to an increased risk of thrombosis.

The formation of blood clots is involved in various substances, including insoluble fibrin, platelets, white blood cells, red blood cells, etc., which together coagulate into small clumps. If blood clots are likened to reinforced concrete, then fibrin is equivalent to steel bars. The most direct way to quickly dissolve a thrombus is to dissolve the fibrin (steel) in its structure. Based on this principle, most thrombolytic drugs currently activate fibrinogen to convert into fibrinolysin, thereby exerting fibrinolytic effects and ultimately dissolving thrombi, such as urokinase, streptokinase, etc. However, due to the fact that these drugs themselves cannot directly act on fibrin, the thrombolysis efficiency is not as effective as the "nattokinase" that can directly act on fibrin.

Direct thrombolysis - Nattokinase is not sensitive to fibrinogen, but can directly hydrolyze cross-linked fibrin, i.e. dissolve formed thrombi;

Indirect thrombolysis - Nattokinase can catalyze the conversion of urokinase to urokinase and stimulate the production of t-PA by vascular endothelial cells. Both urokinase and t-PA can activate plasminogen in the body and dissolve formed thrombi;

In addition, Best nattokinase supplement has a small molecular weight, are easily absorbed by the body, and have a long action time (with a half-life of 8 hours in the body, while urokinase is only 30 minutes). Compared to traditional thrombolytic drugs, they are safer and can be taken orally for daily preventive supplementation.

As an enzyme, the most important concern for everyone is whether oral best natto supplement can smoothly enter the bloodstream and exert its effects. In fact, there is currently human experimental data supporting the feasibility of oral nattokinase capsules.

1. Dissolve thrombus

In 2015, a double-blind, placebo-controlled experiment involving 12 healthy subjects was conducted to investigate the changes in coagulation/fibrinolysis parameters after oral administration of 2000FU of nattokinase (NSK-SD, developed by the Japanese Institute of Biological Sciences) in blood samples at 2, 4, 6, and 8 hours. The experimental report was published in the sub issue of Nature magazine in the UK, Scientific Reports (IF=4.996).

The experiment detected a significant decrease in blood fibrinogen/fibrinogen degradation products in the samples collected at the 4th hour (indicating fibrinogen degradation and thrombolysis), and a continuous decrease in coagulation factor VIll activity was detected at the 4th and 6th hours, further confirming that oral nattokinase not only has thrombolytic and anticoagulant effects.

2. Improve vascular elasticity and reduce atherosclerosis

As a "blood vessel scavenger", best nattokinase supplement also indirectly improve vascular elasticity by dissolving thrombus, alleviate blood pressure rise caused by thrombus, and reduce the risk of atherosclerosis.

The currently largest clinical study was published in the international authoritative cardiovascular journal Frontiers in Cardiovascular Medicine (IF=6.050) in 2022. This study retrospectively analyzed the changes in clinical indicators after 12 months among 1062 subjects who took nattokinase products (3600FU per dose, 3 times daily, totaling 10800FU/day) between 2016 and 2020.

The results showed that supplementation of 10800FU/day nattokinase could effectively control the progression of atherosclerosis and hyperlipidemia, significantly improve the blood lipid level (reduce blood indicators such as total cholesterol TC, total triglyceride TG, low-density lipoprotein cholesterol LDL-C), and no adverse reactions were found. Due to the fact that some participants also consumed both nattokinase and vitamin K2 or aspirin, the relevant data also shows that nattokinase has a certain synergistic effect with vitamin K2 or aspirin.

3. Other potential roles

• Eye and brain health: improving the microcirculation of the eyes and brain

Nattokinase has very good health benefits for the eyes. It not only purifies the blood, dissolves clots that block the microvasculature of the eye, but also reduces the accumulation of cholesterol in the blood vessel wall; In addition, it also has benefits for the prevention of cataracts.

• Respiratory health: Helps dissolve and dilute phlegm and nasal mucus

Nattokinase improves nasal polyps caused by respiratory tract thrombosis. In addition, if mucus such as phlegm is too thick, it will be difficult to expel and cause inflammation, airway obstruction, breathing difficulties, and ultimately lead to the formation of polyps.

2000FU is the recommended dosage given by the European Union, but there are currently studies showing that high FU dosage is more effective. If it is only for maintenance purposes, it is recommended to start at 2000FU/day. If the effect is not significant, it can be gradually increased to 6000FU/day. If you want to exceed this daily dose, it is recommended to consult a professional.

What is FU?

The standard unit for nattokinase products established by the official Japanese Health and Nutrition Food Association is FU (Fiber Unit). Its meaning is the unit that decomposes blood clots, equivalent to the effect of nattokinase.

In summary, many chronic diseases in the human body are associated with accumulated blood clots, and oral best nattokinase supplement can indirectly slow down the progression of vascular sclerosis and hypertension through anti-inflammatory effects; It also has the potential for chronic inflammation management. Especially in the prevention and treatment of cardiovascular and cerebrovascular embolism and thrombotic dementia, it plays a positive role.

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